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  1. General Info
  2. Effects Info
  3. Reference
Drug Details
01. General Information
Name Thymic stromal lymphopoietin
Drug Type Not Available
TTD ID DMOF95
Toxicity Organism Test Type Route(Dose)
Structure 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Decreasing Drug Toxicity
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Combination Pair ID: 859
Ref_1
Pair Name Acteoside, Thymic stromal lymphopoietin
Partner Name Acteoside
Disease Info [ICD-11: 2B33.4] Leukemia Investigative
Gene Regulation Down-regulation Expression BCL2 hsa596
Down-regulation Expression IL1B hsa3553
Down-regulation Expression IL6 hsa3569
Down-regulation Expression MDM2 hsa4193
Down-regulation Expression TNF hsa7124
In Vitro Model HMC-1 Mast cell leukemia Homo sapiens (Human) CVCL_0003
Result These results indicate that acteoside is a specific regulator of MDM2 activation in TSLP-stimulated mast cells, which indicates its potential use for the treatment of mast cell-mediated inflammatory diseases.
03. Reference
No. Title Href
1 Acteoside attenuates TSLP-induced mast cell proliferation via down-regulating MDM2. Int Immunopharmacol. 2015 May;26(1):23-9. doi: 10.1016/j.intimp.2015.03.003. Click
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